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TB testing guide

What is a TB skin test? (PPD / Mantoux test)

A two-visit screening test for tuberculosis exposure — small forearm injection read 48 to 72 hours later.

A TB skin test — formally the Mantoux test or Purified Protein Derivative (PPD) — screens for tuberculosis exposure. A trained healthcare worker injects a small amount of purified TB protein just under the skin of your forearm. You return 48 to 72 hours later for a trained reader to measure the response.

The reader measures the induration (the raised, firm area), not the redness. A positive reaction means your immune system has been exposed to TB bacteria at some point and produced an immune response — but it does not necessarily mean you have active disease. A negative reaction means no induration developed.

The TB skin test is the long-standing standard. It is widely accepted by schools, nursing programs, healthcare employers, childcare programs, and many immigration applications. The cost at our Ashburn lab is $89, which covers both the injection visit and the return reading.

A two-visit requirement is the main downside. If you miss the 48-to-72-hour reading window, the test must be repeated. For clients whose return visit is hard to schedule — and for clients vaccinated with BCG (which can produce false-positive skin reactions) — we recommend the single-visit QuantiFERON-TB Gold blood test instead. Same $89 price.

FAQ

Frequently asked

Specific questions about this topic. Don’t see yours? Call us at 571-500-7030.

What does a "positive" TB skin test mean?

A positive (significant induration) result means your immune system has been exposed to TB bacteria. It does not mean you have active TB disease — follow-up testing (chest X-ray, blood test, or a clinician visit) is needed to determine whether infection is latent or active.

Why is the QuantiFERON test sometimes preferred?

QuantiFERON is a single-visit blood test (no return reading), is not affected by BCG vaccination (which can cause false-positive PPDs), and is generally preferred for nursing students and BCG-vaccinated individuals.

How long is a TB skin test result valid?

Most programs accept the result for 12 months. Many programs (especially healthcare and nursing) require annual TB screening even after a negative result.

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